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AIDS Treatment News Daily Alerts
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Spontaneous reversal of the developmental aging of normal human cells following transcriptional reprogramming
"Conclusion: Prematurely aged (shortened) telomeres appears to be a common feature of iPS cells created by current pluripotency protocols. However, the spontaneous appearance of lines that express sufficient telomerase activity to extend telomere length may allow the reversal of developmental (...)
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Vacc-C5 to be prepared for phase I/II clinical trial
"Research results to date indicate that Vacc-C5 may induce a protective antibody response in HIV patients similar to that found in patients with a very slow or non-progressing disease. This naturally very slow or non-progressing HIV infection observed in a small minority of patients has been (...)
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Chemical in Bananas May Prevent and Treat HIV
"A chemical in bananas has been found to inhibit HIV, according to research findings from a University of Michigan Medical School published in the March 19 issue of the Journal of Biological Chemistry. According to the study authors, this may lead to the development of inexpensive microbicides (...)
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Rates of new HIV diagnoses amongst US gay men 44 times greater than those in other populations
"HIV has a hugely disproportionate impact on gay and other men who have sex with men in the US, according to new figures released by the US Centers for Disease Control and Surveillance (CDC). "Investigators calculated that the rate of new HIV infections amongst gay and bisexual men is 44 times (...)
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HIV Reservoir Found in Blood Progenitor Cells in Bone Marrow
"SUMMARY: HIV can hide in the bone marrow inside hematopoietic progenitor stem cells, even in people with long-term undetectable plasma viral load, according to study results reported in the March 7, 2010 online edition of Nature Medicine. When the cells are forced to differentiate into (...)
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AIDSmeds in San Francisco: Highlights from CROI 2010
"Though this year’s Conference on Retroviruses and Opportunistic Infections (CROI) won’t likely be remembered for HIV prevention or treatment breakthroughs—there weren’t any—it certainly confirmed that research into the virus and its complications continues at a dizzying clip." Read more in POZ, (...)
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HIVandHepatitis.com on Retroviruses conference, related information: LEDGF Integrase Inhibitors and Capsid Assembly Inhibitors Offer New Approaches for Blocking HIV Replication 3-2-2010 ACTG 5202 Shows Abacavir/lamivudine and Tenofovir/emtricitabine Provide Similar HIV Suppression at Low (...)
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Stopping Tenofovir Doesn’t Always Reverse Kidney Damage
"In conclusion, Wever’s group writes, 'improvements in renal function after tenofovir cessation is variable and incomplete, particularly in patients with more gradual decline in GFR who are not receiving a protease inhibitor.' They also suggest using a GFR below 90, as opposed to a CKD-defining (...)
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A highly efficient short hairpin RNA potently down-regulates CCR5 expression in systemic lymphoid organs in the hu-BLT mouse model
"Inhibiting the expression of the HIV-1 coreceptor CCR5 holds great promise for controlling HIV-1 infection in patients. Here we report stable knockdown of human CCR5 by a short hairpin RNA (shRNA) in a humanized bone marrow/liver/thymus (BLT) mouse model." Read more in PubMed.gov, February 25, (...)
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HIV drug that protects a fetus should be avoided for 1 year after childbirth, researchers say
"Women given the human immunodeficiency virus (HIV) prevention drug nevirapine to protect their fetus should not use an HIV-drug regimen that contains nevirapine for at least one year after childbirth, say researchers at the University of Alabama at Birmingham (UAB). "A new UAB study found that (...)